Research progress of anti-hepatitis B virus treatment strategy during pregnancy / 中华临床感染病杂志

The use of antiviral drugs during pregnancy to reduce serum HBV DNA levels can block the mother-to-child transmission.However, clinical studies have shown that neonatal immunization failure may occur in some cases among pregnant women with high HBV DNA load receiving hepatitis B vaccine combined with hepatitis B immunoglobulin(HBIG).This article reviews the recent progress on the antiviral therapy strategies for the use of nucleoside(acid)analogues in pregnant women with high levels of HBV DNA,focusing on the success rate of blocking mother-infant transmission, the safety for both mothers and infants,and the duration of drug use and the time of drug withdrawal.